Here comes PixInsight to the rescue, in particular it's 'Dynamic Background Extraction' , has a clever algorithm to sieve out details from the noise. The images below clearly benefited from it:
Rosette Nebula
AP Mach 1 GTO, 8" Orion Optics UK Newt f/4.5,Baader MPCC, Modified Canon 350D, 11x8min ISO800

M42
AP Mach 1 GTO, 8" Orion Optics UK Newt f/4.5, Baader MPCC, Modified Canon 350D, 4x30s, 5x1min, 5x5min, 3x8min ISO800

NGC3372
AP March 1 GTO, 8' Orion Optics UK Newt f/.5, Baader MPCC, Modified Canon 350D, 6x5min ISO800
